SetBone Medical

Bone cement for treatment of vertebral compression fractures (VCFs)

Technology Development

Business Development





Nimrod Kaufmann
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The Trendlines Group ; the Israel Innovation Authority, Agrilline (CBG)


SetBone Medical introduces a new generation of acrylic bone cement that seeks to provide a safer and more efficient treatment.

SetBone’s proprietary acrylic bone cement does not contain any toxic monomers. It comes in a ready-to-use, prefilled cartridge and can be used right out of the box. No preparations required. The dual paste, mix on injection, allows extended working time. Its low exothermic reaction keeps the cement curing temperature low and prevents damage to surrounding tissue.

Market Need

Osteoporosis leads to 1.5 million fractures each year in the United States, of which 750,000 are vertebral compression fractures (VCFs).

Painful and disfiguring, VCFs often do not respond to conservative treatment such as medication or physical therapy. In the United States more than 100,000 VCFs are treated with bone cement injection (vertebroplasty and kyphoplasty procedures). Developed originally in the 1960’s, acrylic bone cements are widely used for various orthopedic applications, including the support of fractured bones and anchoring of artificial joints. Alongside the clinical efficiency of the acrylic cements there still are risks and limitations. Current acrylic cements require on-site preparation which involves release of toxic monomers. Handling limitations include inconsistent cement viscosity and a short injection time window. In addition, the curing of current acrylic cements in the human body generates heat (exothermic reaction) with high temperatures that damages surrounding tissue.

​The market seeks an acrylic bone cement with improved safety and better handling for the use of bone filler in fractured bones and for anchoring of artificial joints.

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